李晔 副教授 硕士生导师

E-mail：liye918@gmail.com

教育经历

    (1) 2008-09 至 2011-07, 东北农业大学, 动物生物化学与分子生物学, 博士

    (2) 2005-09 至 2008-08, 东北农业大学, 生物化学与分子生物学, 硕士

    (3) 2001-09 至 2005-08, 东北农业大学, 动物医学, 学士

工作经历

    2011-07 至 今, william hill中文网, 威廉希尔

研究方向

   (1) 非编码RNA与脂代谢

(2) 帕金森病、阿兹海默病等神经退行性疾病研究

科研基金

1．云南省“兴滇英才支持计划”入选者，2018-01-2023-12，主持，在研

2．miR-302a通过硫氧还蛋白结合蛋白-2对肝脂代谢调控作用的研究,国家自科基金地区基金项目，81460167，2015-01-2018-12，主持，结题

3．miR-128-3p对肝细胞脂代谢及自噬调控作用的研究，云南省教育厅科技教师类项目，2019J0041，2019-06-2021-05，主持，结题

4．miR-302a通过TBP-2对肝细胞脂代谢调控作用的研究，云南省科技厅科研(人培)项目Y201226098，主持，结题

荣誉奖励

2013年获“红云园丁奖”

2015年获首届“威廉希尔青年教师讲课比赛”优秀奖

代表性论文

1: Li Y, Liang M, Zhang Y, Yuan B, Gao W, Shi Z, Bai J. miR-93, miR-373, and miR-17-5p Negatively Regulate the Expression of TBP2 in Lung Cancer. Front Oncol. 2020 Apr 28;10:526. doi: 10.3389/fonc.2020.00526. PMID: 32426273; PMCID: PMC7212423.

2: Yang L, Guo N, Fan W, Ni C, Huang M, Bai L, Zhang L, Zhang X, Wen Y, Li Y, Zhou X, Bai J. Thioredoxin-1 blocks methamphetamine-induced injury in brain through inhibiting endoplasmic reticulum and mitochondria-mediated apoptosis in mice. Neurotoxicology. 2020 May;78:163-169. doi: 10.1016/j.neuro.2020.03.006. Epub 2020 Mar 20. PMID: 32203791.

3: Bai L, Zhang S, Zhou X, Li Y, Bai J. Brain-derived neurotrophic factor induces thioredoxin-1 expression through TrkB/Akt/CREB pathway in SH-SY5Y cells. Biochimie. 2019 May;160:55-60. doi: 10.1016/j.biochi.2019.02.011. Epub 2019 Feb 20. PMID: 30796965.

4: Guo N, Zhang X, Huang M, Li X, Li Y, Zhou X, Bai J. Geranylgeranylacetone blocks the reinstatement of morphine-conditioned place preference. Neuropharmacology. 2018 Dec;143:63-70. doi: 10.1016/j.neuropharm.2018.09.027. Epub 2018 Sep 18. PMID: 30240785.

5: Huang M, Bai M, Zhang Z, Ge L, Lu K, Li X, Li Y, Zhou X, Guo N, Yang L, Bai J. Downregulation of thioredoxin-1 in the ventral tegmental area delays extinction of methamphetamine-induced conditioned place preference. J Psychopharmacol. 2018 Sep;32(9):1037-1046. doi: 10.1177/0269881118791523. Epub 2018 Aug 23. PMID: 30136629.

6: Huang M, Yan C, Yang X, Zhou X, Lv W, Guo N, Li Y, Bai J. Thioredoxin-1 downregulation in the nucleus accumbens promotes methamphetamine-primed reinstatement in mice. Neuropharmacology. 2018 Sep 1;139:117-123. doi: 10.1016/j.neuropharm.2018.07.003. Epub 2018 Jul 4. PMID: 29981334.

7: Zhang X, Bai L, Zhang S, Zhou X, Li Y, Bai J. Trx-1 ameliorates learning and memory deficits in MPTP-induced Parkinson's disease model in mice. Free Radic Biol Med. 2018 Aug 20;124:380-387. doi: 10.1016/j.freeradbiomed.2018.06.029. Epub 2018 Jun 28. PMID: 29960099.

8: Fan Y, Chen Y, Zhang S, Huang M, Wang S, Li Y, Bai J. Morphine reverses the effects of 1-methyl-4-phenylpyridinium in PC12 cells through activating PI3K/Akt. Int J Neurosci. 2019 Jan;129(1):30-35. doi: 10.1080/00207454.2018.1492575. Epub 2018 Oct 30. PMID: 29936883.

9: Li X, Huang M, Yang L, Guo N, Yang X, Zhang Z, Bai M, Ge L, Zhou X, Li Y, Bai J. Overexpression of Thioredoxin-1 Blocks Morphine-Induced Conditioned Place Preference Through Regulating the Interaction of γ-Aminobutyric Acid and Dopamine Systems. Front Neurol. 2018 May 2;9:309. doi: 10.3389/fneur.2018.00309.

PMID: 29770121; PMCID: PMC5941988.

10: Yang L, Guo Y, Huang M, Wu X, Li X, Chen G, Li Y, Bai J. Thioredoxin-1 Protects Spinal Cord from Demyelination Induced by Methamphetamine through Suppressing Endoplasmic Reticulum Stress and Inflammation. Front Neurol. 2018 Feb 6;9:49. doi: 10.3389/fneur.2018.00049. PMID: 29467717; PMCID: PMC5808126.