白洁 教授 硕（博）士生导师

 

 

 

E-mail：jiebai662001@126.com

教育经历

1983.9-1988.7 昆明医科大学 学士

1999.4-2003.3 日本京都大学 博士

工作经历

2022-至今  英国威廉希尔公司 教授

1988-1990  昆明市人民医院 住院医师

1990-1997  云南省人民医院 主治医师

2003-2005  美国弗吉尼亚大学医学部 博士后

2005-至今  william hill中文网生科院、威廉希尔 教授

研究方向

硫氧还蛋白1（Trx1）在神经系统的作用和Trx1相关信号转导途径的研究，药物成瘾和神经退行性疾病。

科研基金

云南省教育厅重点实验室主任及创新团队带头人。

在研以及完成国家级项目及省部级10余项，其中国家自然科学基金5项，2项为国家自然科学基金云南省联合基金重点项目。

荣誉奖励

云南省“兴滇英才支持计划”入选者-云岭学者；

云南省中青年学术和技术带头人；

云南省有突出贡献优秀专业技术人才。

云南省自然科学二等奖（第一）。

代表性论文

1: Wang H, Dong X, Awan MUN, Bai J*. Epigenetic mechanisms involved in methamphetamine addiction. Front Pharmacol. 2022 Aug 26;13:984997. doi: 10.3389/fphar.2022.984997.

 

2: Zhang X, Zhang R, Nisa Awan MU, Bai J. The Mechanism and Function of Glia in Parkinson's Disease. Front Cell Neurosci. 2022 May 26;16:903469. doi: 10.3389/fncel.2022.903469.

 

3: Liu N, Bai L, Lu Z, Gu R, Zhao D, Yan F, Bai J*. TRPV4 contributes to ER stress and inflammation: implications for Parkinson's disease. J Neuroinflammation. 2022; 19(1):26. doi: 10.1186/s12974-022-02382-5.

 

4: Awan MUN, Yan F, Mahmood F, Bai L, Liu J, Bai J*. The Functions of Thioredoxin 1 in Neurodegeneration. Antioxid Redox Signal. 2021 Dec 31. doi: 10.1089/ars.2021.0186.

 

5: Guo N, Zhang L, Fan W, Bai L, Zhang X, Shi Z, Bai J*. Inhibition of Geranylgeranylacetone on cholecystokinin-B receptor, BDNF and dopamine D1 receptor induced by morphine. Biochem Biophys Res Commun. 2022; 588:23-28.doi: 10.1016/j.bbrc.2021.12.034.

 

6: Shi ZZ*, Tao H, Fan ZW, Song SJ, Bai J*. Prognostic and Immunological Role of Key Genes of Ferroptosis in Pan-Cancer. Front Cell Dev Biol. 2021; 9:748925. doi: 10.3389/fcell.2021.748925.

 

7: Zhang X, Deng R, Zhang S, Deng J, Jia JJ, Sun B, Zhou X, Bai J*. Thioredoxin-1 regulates calcium homeostasis in MPP+ /MPTP-induced Parkinson's disease models. Eur J Neurosci. 2021;54(3):4827-4837. doi: 10.1111/ejn.15355.

 

8: Bai L, Yan F, Deng R, Gu R, Zhang X, Bai J. Thioredoxin-1 Rescues MPP+/MPTP-Induced Ferroptosis by Increasing Glutathione Peroxidase 4. Mol Neurobiol. 2021 Jul;58(7):3187-3197. doi: 10.1007/s12035-021-02320-1.

 

9: Klionsky DJ, et al Bai J, et al, Tong CK. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 2021;17(1):1-382. doi: 10.1080/15548627.2020.1797280.

 

10: Liu N, Liu J, Wen X, Bai L, Shao R, Bai J*. TRPV4 contributes to ER stress: Relation to apoptosis in the MPP+-induced cell model of Parkinson's disease. Life Sci. 2020;261:118461. doi: 10.1016/j.lfs.2020.118461.

 

11: Shi ZZ, Wang WJ, Chen YX, Fan ZW, Xie XF, Yang LY, Chang C, Cai Y, Hao JJ,Wang MR*, Bai J*. The miR-1224-5p/TNS4/EGFR axis inhibits tumour progression in oesophageal squamous cell carcinoma. Cell Death Dis. 2020;11(7):597. doi:10.1038/s41419-020-02801-6.

 

12: Yang L, Guo N, Fan W, Ni C, Huang M, Bai L, Zhang L, Zhang X, Wen Y, Li Y, Zhou X, Bai J*. Thioredoxin-1 blocks methamphetamine-induced injury in brain through inhibiting endoplasmic reticulum and mitochondria-mediated apoptosis in mice. Neurotoxicology. 2020; 78:163-169. doi: 10.1016/j.neuro.2020.03.006.

 

13: Li Y, Liang M, Zhang Y, Yuan B, Gao W, Shi Z*, Bai J*. miR-93, miR-373, and miR-17-5p Negatively Regulate the Expression of TBP2 in Lung Cancer. Front Oncol. 2020;10:526. doi: 10.3389/fonc.2020.00526.

 

14: Bai L, Zhang S, Zhou X, Li Y, Bai J*. Brain-derived neurotrophic factor induces thioredoxin-1 expression through TrkB/Akt/CREB pathway in SH-SY5Y cells. Biochimie. 2019;160:55-60. doi: 10.1016/j.biochi.2019.02.011.

 

15: Fan Y, Chen Y, Zhang S, Huang M, Wang S, Li Y*, Bai J*. Morphine reverses the effects of 1-methyl-4-phenylpyridinium in PC12 cells through activating PI3K/Akt. Int J Neurosci. 2019;129(1):30-35. doi:10.1080/00207454.2018.1492575.

 

16: Shi ZZ, Fan ZW, Chen YX, Xie XF, Jiang W, Wang WJ, Qiu YT, Bai J*. Ferroptosis in Carcinoma: Regulatory Mechanisms and New Method for CancerTherapy. Onco Targets Ther. 2019; 12:11291-11304. doi:10.2147/OTT.S232852.

 

17: Guo N, Zhang X, Huang M, Li X, Li Y, Zhou X, Bai J*. Geranylgeranylacetone blocks the reinstatement of morphine-conditioned place preference.Neuropharmacology. 2018; 143:63-70. doi: 10.1016/j.neuropharm. 2018. 09.027.

 

18: Huang M, Bai M, Zhang Z, Ge L, Lu K, Li X, Li Y, Zhou X, Guo N, Yang L, Bai J*. Downregulation of thioredoxin-1 in the ventral tegmental area delays extinction of methamphetamine-induced conditioned place preference. J Psychopharmacol. 2018; 32(9):1037-1046. doi: 10.1177/0269881118791523.

 

19: Huang M, Yan C, Yang X, Zhou X, Lv W, Guo N, Li Y*, Bai J*. Thioredoxin-1 downregulation in the nucleus accumbens promotes methamphetamine-primed reinstatement in mice. Neuropharmacology. 2018; 139:117-123. doi:10.1016/j. neuropharm.2018.07.003.

 

20: Zhang X, Bai L, Zhang S, Zhou X, Li Y*, Bai J*. Trx-1 ameliorates learning and memory deficits in MPTP-induced Parkinson's disease model in mice. Free Radic Biol Med. 2018;124:380-387. doi: 10.1016/j.freeradbiomed.2018.06.029.

 

 

21: Li X, Huang M, Yang L, Guo N, Yang X, Zhang Z, Bai M, Ge L, Zhou X, Li Y, Bai J*. Overexpression of Thioredoxin-1 Blocks Morphine-Induced Conditioned Place Preference Through Regulating the Interaction of γ-Aminobutyric Acid and Dopamine Systems. Front Neurol. 2018 May 2;9:309. doi: 10.3389/fneur.2018.00309.

 

22: Yang L, Guo Y, Huang M, Wu X, Li X, Chen G, Li Y, Bai J*. Thioredoxin-1 Protects Spinal Cord from Demyelination Induced by Methamphetamine through Suppressing Endoplasmic Reticulum Stress and Inflammation. Front Neurol. 2018; 9:49. doi: 10.3389/fneur.2018.00049.

 

23: Mei LL, Qiu YT, Wang WJ, Bai J*, Shi ZZ*. Overexpression of microRNA-1470 promotes proliferation and migration, and inhibits senescence of esophageal squamous carcinoma cells. Oncol Lett. 2017;14(6):7753-7758. doi: 10.3892/ol.2017.7190.

 

24: Mei LL, Wang WJ, Qiu YT, Xie XF, Bai J*, Shi ZZ*. miR-125b-5p functions as a tumor suppressor gene partially by regulating HMGA2 in esophageal squamous cell carcinoma. PLoS One. 2017; 12(10):e0185636. doi: 10.1371/journal.pone.0185636.

 

25: Mei LL, Wang WJ, Qiu YT, Xie XF, Bai J*, Shi ZZ*. miR-145-5p Suppresses Tumor Cell Migration, Invasion and Epithelial to Mesenchymal Transition by Regulating the Sp1/NF-κB Signaling Pathway in Esophageal Squamous Cell Carcinoma. Int J Mol Sci. 2017 Aug 23;18(9):1833. doi: 10.3390/ijms18091833.

 

26: Huang M, Kong L, Yang L, Li X, Zhou X, Li Y, Bai J*. The role of thioredoxin-1 in resisting methamphetamine-induced rewarding effect. Behav Brain Res. 2018;337:280-286. doi: 10.1016/j.bbr.2017.07.047.

 

27: Chen G, Li X, Huang M, Zhou X, Li Y, Mao X, Bai J*. The Role of Thioredoxin-1 in Suppression Sepsis Through Inhibiting Mitochondrial-Induced Apoptosis in Spleen. Shock. 2017; 47(6):753-758. doi: 10.1097/SHK.0000000000000789.

 

28: Cai Y, Zhang X, Zhou X, Wu X, Li Y, Yao J, Bai J*. Nicotine suppresses the neurotoxicity by MPP+/MPTP through activating α7nAChR/PI3K/Trx-1 and suppressing ER stress. Neurotoxicology. 2017; 59:49-55. doi:10.1016/j.neuro. 2017.01.002.

 

29: Chen G, Li X, Huang M, Li M, Zhou X, Li Y, Bai J*. Thioredoxin-1 IncreasesSurvival in Sepsis by Inflammatory Response Through Suppressing Endoplasmic Reticulum Stress. Shock. 2016 Jul;46(1):67-74. doi:10.1097/SHK.0000000000000570.

 

30: Klionsky DJ, et al, Bai J, et al. Zughaier SM. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356.

 

31: Wu XL, Li X, Li Y, Kong LP, Fang JL, Zhou XS, Li M, Jia JJ, Bai J*. The overexpression of Thioredoxin-1 suppressing inflammation induced by methamphetamine in spleen. Drug Alcohol Depend. 2016;159:66-71. doi: 10.1016/j. drugalcdep.2015.11.021.

 

32: Jia JJ, Zeng XS, Yang LH, Bai J*. The epinephrine increases tyrosine hydroxylase expression through upregulating thioredoxin-1 in PC12 cells. Biochimie.115:52-8. doi: 10.1016/j.biochi.2015.04.022.

 

33: Jia JJ, Zeng XS, Zhou XS, Li Y, Bai J*. The induction of thioredoxin-1 by epinephrine withdraws stress via interaction with β-arrestin-1. Cell Cycle. 2014;13(19):3121-31. doi: 10.4161/15384101.2014.949214.

 

34: Chen W, Zeng X, Luo F, Lv T, Zhou X, Bai J*. The decreased expression of thioredoxin-1 in brain of mice with experimental autoimmune myasthenia gravis. Neuromuscul Disord. 2014;24(8):726-35. doi: 10.1016/j.nmd.2014.05.001.

 

35: Zeng XS, Zhou XS, Luo FC, Jia JJ, Qi L, Yang ZX, Zhang W, Bai J*. Comparative analysis of the neuroprotective effects of ginsenosides Rg1 and Rb1 extracted from Panax notoginseng against cerebral ischemia. Can J Physiol Pharmacol. 2014;92(2):102-8. doi: 10.1139/cjpp-2013-0274.

 

36: Bai J*, Wang S. Panaxatriol saponin ameliorated liver injury by acetaminophen via restoring thioredoxin-1 and pro-caspase-12. Liver Int. 2014 Jul;34(6):963. doi: 10.1111/liv.12463.

 

37: Zeng XS, Jia JJ, Kwon Y, Wang SD, Bai J*. The role of thioredoxin-1 in suppression of endoplasmic reticulum stress in Parkinson disease. Free Radic Biol Med. 2014 Feb;67:10-8. doi: 10.1016/j.freeradbiomed.2013.10.013.

 

38: Wang S, Wang X, Luo F, Tang X, Li K, Hu X, Bai J*. Panaxatriol saponin ameliorated liver injury by acetaminophen via restoring thioredoxin-1 and pro-caspase-12. Liver Int. 2014;34(7):1068-73. doi: 10.1111/liv.12329.

 

39: Lv T, Li Y, Jia J, Shi Z, Bai J*. Protective effect of geranylgeranylacetone against methamphetamine-induced neurotoxicity in rat pheochromocytoma cells. Pharmacology. 2013;92(3-4):131-7. doi: 10.1159/000353213.

 

40: Jia JJ, Zeng XS, Li Y, Ma S, Bai J*. Ephedrine induced thioredoxin-1 expression through β-adrenergic receptor/cyclic AMP/protein kinase A/dopamine-and cyclic AMP-regulated phosphoprotein signaling pathway. Cell Signal. 2013;25(5):1194-201. doi: 10.1016/j.cellsig.2013.02.007.