孙博 讲师 硕士生导师

E-mail：sunbo1025@hotmail.com

教育经历:

  2004-2008 哈尔滨医科大学 药学 学士

  2008-2013 哈尔滨医科大学 药理学 博士

工作经历：

2013-2018 加拿大卡尔加里大学 Libin 心血管研究中心 博士后

2013-至今 william hill中文网 威廉希尔 讲师

研究方向： 

细胞内钙离子释放通道，心律失常

科研基金：

心脏兰尼碱受体功能缺失型突变致心律失常与心源性猝死的作用及机制研究.国家自然科学基金青年项目. 2020.01-2022.12.在研

荣誉奖励:

1. Alberta Innovates Health Solutions- Award of Postgraduate fellowship. (2014-2017)

2. Heart and Stroke Foundation- Award Research Fellowship award (2014-2016)

3. Selected Presentation Award of Tina Haworth Cardiovascular Research Day (2018)

4. Top Basic Research Article Award of Hypertension in Year 2013. (2014)

5. LCIA Trainee Excellence in Research. (2016)

代表性论文:

1. Sun B, Yao J, Ni M, Wei J, Zhong X, Guo W, Zhang L, Wang R, Belke D, Chen YX, Lieve KVV, Broendberg AK, Roston TM, Blankoff I, Kammeraad JA, von Alvensleben JC, Lazarte J, Vallmitjana A, Bohne LJ, Rose RA, Benitez R, Hove-Madsen L, Napolitano C, Hegele RA, Fill M, Sanatani S, Wilde AAM, Roberts JD, Priori SG, Jensen HK, Chen SRW. Cardiac ryanodine receptor calcium release deficiency syndrome. Sci Transl Med. 2021 Feb 3;13(579):eaba7287.

2. Guo W, Wei J, Estillore JP, Zhang L, Wang R, Sun B#, Chen SRW#. RyR2 disease mutations at the C-terminal domain intersubunit interface alter closed-state stability and channel activation. J Biol Chem. 2021 Jul;297(1):100808.

3. Sun B, Yao J, Chen AW, Estillore JP, Wang R, Back TG, Chen SRW. Genetically and pharmacologically limiting RyR2 open time prevents neuronal hyperactivity of hippocampal CA1 neurons in brain slices of 5xFAD mice. Neurosci Lett. 2021 Jul 27;758:136011.

4. Yao J*, Sun B*, Institoris A, Zhan X, Guo W, Song Z, Liu Y, Hiess F, Boyce AKJ, Ni M, Wang R, Ter Keurs H, Back TG, Fill M, Thompson RJ, Turner RW, Gordon GR, Chen SRW. Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation. Cell Rep. 2020 Sep 22;32(12):108169.

5. Sun B, Wei J, Zhong X, Guo W, Yao J, Wang R, Vallmitjana A, Benitez R, Hove-Madsen L, Chen SRW. The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca²⁺-ATPase, is a major determinant of Ca²⁺ alternans in intact mouse hearts. J Biol Chem. 2018 Aug 31;293(35):13650-13661.

6. Sun B, Guo W, Tian X, Yao J, Zhang L, Wang R, Chen SR. The Cytoplasmic Region of Inner Helix S6 Is an Important Determinant of Cardiac Ryanodine Receptor Channel Gating. J Biol Chem. 2016 Dec 9;291(50):26024-26034.

7. Lu J*, Sun B*, Huo R, Wang YC, Yang D, Xing Y, Xiao XL, Xie X, Dong DL. Bone morphogenetic protein-2 antagonizes bone morphogenetic protein-4 induced cardiomyocyte hypertrophy and apoptosis. J Cell Physiol. 2014 Oct;229(10):1503-10.

8. Sun B, Huo R, Sheng Y, Li Y, Xie X, Chen C, Liu HB, Li N, Li CB, Guo WT, Zhu JX, Yang BF, Dong DL. Bone morphogenetic protein-4 mediates cardiac hypertrophy, apoptosis, and fibrosis in experimentally pathological cardiac hypertrophy. Hypertension. 2013 Feb;61(2):352-60. （Editor’ s pick, Top Basic Research Paper in 2013）

9. Sun B, Sheng Y, Huo R, Hu CW, Lu J, Li SL, Liu X, Wang YC, Dong DL. Bone morphogenetic protein-4 contributes to the down-regulation of Kv4.3 K+ channels in pathological cardiac hypertrophy. Biochem Biophys Res Commun. 2013 Jul 12;436(4):591-4.

10. Sheng Y*, Sun B*, Guo WT, Zhang YH, Liu X, Xing Y, Dong DL. 3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy. Biochem Biophys Res Commun. 2013 Mar 1;432(1):5-9.